Advantages of time-dependent diffusion MRI for quantitative microstructural mapping in breast tumors
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Time-dependent diffusion MRI (TD-MRI) can measure tumor tissue microstructure, but its effectiveness in differentiating benign from malignant breast tumors is unclear. This study aims to investigate the diagnostic value of TD-MRI microstructural features for distinguishing between benign and malignant breast tumors. Methods: This prospective study included 44 patients with malignant breast tumors and 28 with benign tumors. All subjects underwent the IMPULSED protocol on a 3.0-T MRI scanner. Imaging data were analyzed using least squares fitting in MATLAB, yielding Dex (extracellular diffusivity), Vin (intracellular volume fraction), Dmean (cell diameter), Vin/Dmean, and ADC values. The molecular subtypes of breast cancer are classified based on immunohistochemistry (IHC) results. Results: /ms, p>0.05). Strong correlations were observed: positive between ADC and Dmean, and negative between ADC and both Vin and Vin/Dmean. AUC values for Vin (0.92; 95% CI: 0.86-0.99), and Vin/Dmean (0.91; 95% CI: 0.83-0.98) surpassed those for ADC. Conclusion: TD-MRI microstructure mapping effectively differentiates benign from malignant breast tumors, highlighting its potential to improve diagnostic accuracy for lesions.
Source: Frontiers in Oncology
Authors: Lei Bao, Sijie Li, Zhuo Wang, Yang Sun, Ying Qiu, Zhiwei Shen, Xiaoxiao Zhang, Xue Chen, Xiaoxiao Zhang, Junyu Zhang, Tiefeng Ji
Institution: First Hospital of Jilin University
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408825550