Work

Low-cost Continuous Manufacturing of Microfluidic Platforms for Remote Automated Room Temperature X-ray Protein Crystallography

Year: 2024

Type: conference-paper

Abstract: X-ray crystallography is one of the leading tools to analyze the 3D structure, and therefore function of proteins and other biological macromolecules.Traditional methods of mounting individual crystals for X-ray diffraction analysis are tedious and can damage fragile protein crystals.Furthermore, the advent of serial crystallography methods explicitly requires the mounting of large numbers of crystals.To address this, we have developed the array-type fixed-target device for X-ray crystallography (AFD-X), which simplifies the process of mounting numerous protein crystals for diffraction analysis and can be manufactured at large scale.

DOI: 10.70477/wjiw3272

Authors: Sarthak Saha, Yaozu Chen, Silvia Russi, Darya Marchany-Rivera, Aina Cohen, Sarah Perry

Institutions: University of Massachusetts Amherst, SLAC National Accelerator Laboratory

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

OpenAlex ID: W4408828173

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