Microfluidic Multi-faceted Bladder Tumor Model for Biofilm Potentiates Cancer-promoting Effects
Year: 2024
Type: conference-paper
Abstract: We developed a novel microfluidic bladder tumor model (TAMPIEB) explores how bacterial biofilms impact tumor-associated macrophages (TAMs) within the tumor microenvironment (TME).Our results demonstrates that biofilms promote a phenotypic shift in TAMs from a pro-inflammatory M1-like to a pro-tumor M2-like state, influencing cancer progression by reducing apoptosis susceptibility, enhancing cell viability, and encouraging metastasis.This highlights that extratumoral bacterial biofilms can protect tumors from immune responses, suggesting potential strategies for combined anti-biofilm and immunotherapy in clinical settings.This provides valuable insights into the role of biofilm-induced inflammation in tumor dynamics.
DOI: 10.70477/acle6892
Authors: Mingze Zhu, Yanlin Deng, Bee Luan
Institution: City University of Hong Kong
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Funder: City University of Hong Kong
OpenAlex ID: W4408828189