Concentration-based Anticancer Drug Sorting for in Vitro Combinatorial Efficacy Testing and Prediction Using Magnetic Microfluidic Device
Year: 2024
Type: conference-abstract
Abstract: We introduce a low-cost, reusable magnetic microfluidic device (MMD) with a circularly designed interdigitated electrode (IDE) for screening the most effective combinations of magnetically controlled anticancer drugs (MAD).The device enables concentration-based sorting and label-free quantification, facilitating drug dose testing (IC50) on breast cancer cells (MCF7) with just 5 concentrations (10 µg mL -1 -500 µg mL -1 ) collected across the designated well.As a proof of concept study, we injected Curcumin (A), Paclitaxel (B), and Quercetin (C) as an anticancer drug into the device for combinatorial testing and prediction for all possible concentration combinations.
DOI: 10.70477/raic8352
Authors: Vinit Yadav, Preetha Ganguly, Prashant Mishra, Samaresh Das, Dhiman Mallick
Institution: Indian Institute of Technology Delhi
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4408828331