A Novel Device for Self-powered Lyophilized Vaccine Reconstitution and Intradermal Delivery
Year: 2024
Type: conference-paper
Abstract: Due to the complexity of the Mantoux technique for intradermal (ID) vaccine administration, requiring sufficiently trained healthcare personnel [1], the intramuscular route remains the standard clinical practice [2].One potential solution to enable painless and user-friendly ID vaccine administration are microneedles which might, via coupling to delivery systems, empower self-administration.Previously reported delivery devices required manual activation [3] (being user-friendly, but advanced handling of vaccine not possible) or required external pumps [4] (advanced vaccine handling, but not user-friendly).Here, we present a novel, self-powered microfluidic device that enables (1) on-chip reconstitution and homogenization of lyophilized vaccine and (2) reproducible subsequent ID delivery by using the iSIMPLE technology [5][6].To our knowledge, this is the first report of a device enabling these two steps upon a user-friendly single activation step.
DOI: 10.70477/czln9853
Authors: Wannes Verbist, Elias Broeckhoven, Pieter De, Lorenz Van, Dries Vloemans, Lotte Coelmont, Francesco Dal, Pedro Fardim, Kai Dallmeier, Jeroen Lammertyn
Institutions: KU Leuven, Rega Institute for Medical Research
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: gold
Funder: KU Leuven
Award: G7557195885
OpenAlex ID: W4408828338