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Novel zerumbone-secondary amide hybrids: ultrasonic synthesis, cytotoxic evaluation, molecular docking and in silico ADMET studies

Year: 2025
Type: article
Abstract: , comparable to those of zerumbone and ellipticine. Docking studies revealed a strong correlation between the biological activity of zerumbone-secondary amide hybrids and their binding affinity to EGFR tyrosine kinase, further highlighting the crucial role of secondary amide groups in enhancing their anticancer potential. Furthermore, pharmacokinetic predictions indicate that compounds 4c, 4g, and 4i possess favorable drug-like properties, reinforcing their potential as lead candidates for anticancer drug development.
Source: RSC Advances
DOI: 10.1039/d5ra01215e
Authors: Pham The Chinh, Pham Thi Tham, Vu Thi Lien, Dao Thi Nhung, Le Thi Thuy Loan, Vu Thi Thu Le, Vu Tuan Kien, Cao Thanh Hai, Phan Thanh Phuong
Institutions: Trường Đại học Khoa học, Hanoi University of Industry, Vietnam National University, Hanoi, VNU University of Science, Tay Nguyen University, Thai Nguyen University of Agriculture and Forestry
Language: English
Subfield: Pharmacology
Open Access status: gold
Estimated APC paid: $1,042
OpenAlex ID: W4408829191
FWCI: 3.521
Cites: 33
Cited by: 4
Related to: 10