Work

IL-6 induces mitochondrial ROS production and blunts NO bioavailability in human aortic endothelial cells

Year: 2025

Type: article

Abstract: In this study, we provide evidence that IL-6 induces mitochondrial ROS production, which impairs nitric oxide bioavailability in human aortic endothelial cells. This finding adds an important perspective to the existing literature on the mechanism by which IL-6 contributes to endothelial dysfunction.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00289.2024

Authors: Prema Velusamy, David J. Buckley, Jody L. Greaney, Adam J. Case, Paul J. Fadel, Daniel W. Trott

Institutions: The University of Texas at Arlington, University of Delaware, Texas A&M University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Institute on Aging, National Institute of Mental Health