Interleukin-13 Assessment in Gingival Crevicular Fluid of Patients with Periodontal Disease
Year: 2025
Type: article
Study design: Observational Study
Abstract: The present study holds significant potential to assess interleukin 13 (IL-13) levels in Crevicular Gingival Fluid (CGF) as a potential immunological marker for bone remodeling in subjects with periodontal disease. Thirty-nine subjects were included, with 19 diagnosed with gingivitis and 20 with periodontitis. The latter were classified following the new classification of periodontal and peri-implant diseases in stages I (6%), II (6%), III (6%), and IV (2%). Crevicular gingival fluid was meticulously collected with filter paper strips. Volume quantification was obtained with Periotron 8000® and analyzed by ELISA, ensuring the accuracy of our results. Diagnosed gingivitis patients showed a mean IL-13 level in CGF of 4.42 ± 7.5 pg/μl; in contrast, patients diagnosed in stage II of periodontitis showed higher (44.3 ± 7.5 pg/μl), followed by patients in stage III (27.5 ± 4.3 pg/μl), stage IV (25.4 ± 10.9 pg/μl) and stage I (13.8 ± 9.3 pg/μl). Due to its role in periodontitis, IL-13 might be a possible immunological marker to differentiate between bone remodeling between gingivitis and periodontitis. IL-13 might be an immunological marker playing a relevant bone role in periodontitis.
Source: RA Journal Of Applied Research
Authors: Viridiana Altamirano Paredes, Susana Aurora Macín Cabrera, Departamento de Atención a la Salud. Universidad Autónoma Metropolitana Xochimilco. Calz. del Hueso 1100, Coapa, Villa Quietud, Coyoacán, 04960, Ciudad de México, México., Laura Estela Castrillón Rivera, Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Xochimilco. Calz. del Hueso 1100, Coapa, Villa Quietud, Coyoacán, 04960, Ciudad de México, México., Jorge Ismael Castañeda Sánchez, Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana Xochimilco. Calz. del Hueso 1100, Coapa, Villa Quietud, Coyoacán, 04960, Ciudad de México, México., José de Jesús Juárez Sandoval, Laboratorio de Farmacia Molecular y Liberación Controlada. Universidad Autónoma Metropolitana Xochimilco. Calz. del Hueso 1100, Coapa, Villa Quietud, Coyoacán, 04960, Ciudad de México, México.
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408833550