Work

Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study

Year: 2025

Type: article

Abstract: Background: Hyperuricemia, a risk factor for gout and cardiovascular diseases, has been linked to various metabolic disorders. This study investigates the association between the cardiometabolic index (CMI) and hyperuricemia. Methods: Using the National Health and Nutrition Examination Survey 1999-2018 data from 23,212 participants, we employed survey-weighted logistic regression to quantify the CMI-hyperuricemia relationship. Generalized additive models explored potential nonlinear relationships, with two-piecewise logistic regression identifying inflection points. Stratified analyses across demographic and health subgroups assessed relationship consistency. Results: We found a significant association between higher CMI and increased hyperuricemia and identified a nonlinear relationship, characterized by a faster risk increase at lower CMI levels and slower at higher levels. This pattern remained consistent across all demographic and health subgroups. Conclusions: Higher CMI significantly predicts hyperuricemia across diverse populations, with a pronounced nonlinear association. This pattern underscores the importance of early intervention, emphasizing the need for personalized risk assessments and targeted strategies.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2025.1459946

Authors: Xumei Yang, Yulan Luo, Wei Lai

Institutions: Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801