The Role of Vitamin C in the Modulation of Toxicological Effect of Crude Oil Vapour on the Activities of Transaminases of Heart of Albino Rats
Year: 2025
Type: article
Abstract: This study was conducted to assess the toxic effects of crude oil vapor and oral administration of vitamin C on rats' cellular systems using various routes of administration and the potential involvement of oxidative stress in the mechanism of action. Forty-eight albino rats were split into two main groups (24 male and 24 female): control, vitamin C, group A (25%) and group B (50%) and group C (75%) and group D (100%). Exposure to petroleum products through inhalation and oral administration of vitamin C has been linked to elevated blood pressure, but the mechanism of action has not been fully explained. As mentioned above, each group was further broken into six subgroups, each containing four rats. No therapy was administered to the control. The duration of each exposure and administration was three weeks. When compared to control groups, the results indicated that the treated groups' blood pressure and pulse rate were significantly higher (p<0.05). Research has demonstrated that breathing in crude oil vapor does not kill living things. This is in line with earlier research showing that rats exposed to crude oil vapor for 6–13 weeks survived. Rats' weights in the exposed and control groups were tracked and reported as weekly percentage weight gain (PWG). Growth retardation and weight loss are thought to be the result of complex interactions between different components of crude oil and a signaling pathway involving intercellular and molecular mechanisms that suppress growth stimulatory signals and stimulate growth stimulatory pathways. Severe and perhaps fatal weight loss in rats may occasionally be linked to petroleum exposure.
Authors: Adeyemi ., Adeyemi ., Nwogbu Peter Chinedu
Institution: Federal University of Petroleum Resource Effurun
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4408843341