Work

Longitudinal changes in peritoneal solute transport rate and the impact of lower glucose degradation product glucose dialysates

Year: 2025

Type: article

Abstract: INTRODUCTION: Peritoneal solute transfer rates (PSTR) are reported to increase with time. Changes in PSTR were reviewed in long-term peritoneal dialysis (PD) patients to determine whether lower glucose degradation products (low GDP) dialysates prevented an increase in PSTR. METHODS: PSTR was determined with a 4-h peritoneal equilibrium test with a 2.0 L 22.7 g/L glucose dialysate. RESULTS: One hundred twenty-three PD patients treated for ≥4 years, 47.2% male, age 61 ± 16 years, 31.7% diabetic. Initially, 15.6% were treated with low GDP dialysates, which rose to 44.7% at 6 years. Creatinine PSTR increased with standard glucose dialysates (0.72 ± 0.1 at Year 3 to 0.79 ± 0.1 Year 5 and 0.82 ± 0.1 Year 6, p < 0.05), whereas PSTR was stable and lower with low GDP dialysates (0.71 ± 0.1, 0.65 ± 0.1, 0.68 ± 0.1); p < 0.001 for Years 5 and 6. CONCLUSION: Exposure to standard glucose dialysates resulted in faster peritoneal solute transfer rates over time, whereas peritoneal solute transfer rates appeared more stable with lower glucose degradation products dialysates.

Source: Therapeutic Apheresis and Dialysis

DOI: 10.1111/1744-9987.70012

Author: Andrew Davenport

Institutions: The Royal Free Hospital, University College London

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,350