Work

Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection

Year: 2025

Type: article

Abstract: BACKGROUND: Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection. METHODS: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines. RESULTS: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001). CONCLUSIONS: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiaf149

Authors: Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,763