Work

MLO-Y4 fluid flow shear stress conditioned media enhances cardiac contractility and intracellular Ca 2+

Year: 2025

Type: article

Abstract: The skeletal system operates as an endocrine organ, releasing factors that impact multi-tissue physiology. The results obtained in this study demonstrate that conditioned media collected from MLO-Y4 osteocytes exposed to fluid flow shear stress increases cardiomyocyte intracellular calcium and enhances cardiac contractility in vitro. These results support the concept of bone-heart cross talk that may have implications in exercise training, reduced-function settings such as bedrest, and the interplay between bone and heart health.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00287.2024

Authors: Anuhya Dayal, Mark Gray, Julian A. Vallejo, Nuria Lara-Castillo, Mark L. Johnson, Michael J. Wacker

Institution: University of Missouri–Kansas City

Language: English

Topic: Spaceflight effects on biology

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Missouri-Kansas City, National Institutes of Health, National Institute on Aging