Work

Development of a preclinical model of ICU-associated sleep fragmentation and effects on pneumonia recovery in mice

Year: 2025

Type: article

Abstract: The study of sleep and its interaction with critical illness has been limited partly due to a paucity of representative models. We developed an ICU-associated sleep fragmentation model that recapitulates many of the key features of sleep experienced by patients in the intensive care unit. Furthermore, we observed delayed recovery in lung injury in an S. pneumoniae murine model when exposed to ICU sleep fragmentation.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00210.2024

Authors: Mahendra Damarla, Karthik Suresh, Linda Zheng, Kathleen Carino, Melissa Turner, Othello Del Rosario, Franco D’Alessio, Andres Villabona-Rueda, Neil Aggarwal, Ananya Mukandan, Alessandro D’Alessio, Neha Skandan, Samuel Murray, Naina Gour, Stephane Lajoie, Kimberly M. Davis, Larissa A. Shimoda, Naresh M. Punjabi

Institutions: Johns Hopkins University, University of Miami, University of Colorado Anschutz

Language: English

Topic: Intensive Care Unit Cognitive Disorders

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, Congressionally Directed Medical Research Programs

Awards: G1515313123, G2221158864, Role of Sleep Disruption on Development and Recovery from Lung Injury

OpenAlex ID: W4408848323

FWCI:

Cites: 43

Cited by:

Related to: 10