Work

Update on the relevance of mechanobiological mechanisms in lung cancer

Year: 2025

Type: article

Abstract: • Lung is a mechanoresponsive tissue and mechanotransduction is implicated in all steps of lung tumorigenesis. • Features of the TME, including alterations of the ECM and the role CAFs, form reciprocal mechanobiological interactions with lung cancer cells facilitating tumor progression. • Intracellular protein molecules which are involved in cytoskeletal remodelling participate in mechano-induced molecular mechanisms. • The transcriptional effectors YAP/TAZ integrate mechanical signals and are engaged in mechanisms of aggressive phenotypes, including drug resistance, in lung cancer subtypes. Lung tumorigenesis is characterized by mechanical perturbations at the molecular level that affect cancer development, progression and drug efficacy. Tumor expansion, alterations in the matrix stiffness and aberrant mechanical inputs lead to distorted mechanobiology of cancer and stromal cells. This dysregulation is accompanied by oncogenic mechanosignaling facilitating their invasion, migration and immune evasion. A growing volume of data highlight that such molecular events are translated to clinical phenotypes, which encompass a distinct group of oncogenic molecular mechanisms, prognostic and predictive biomarkers as well as putative therapeutic targets in lung cancer.

Source: Translational Oncology

DOI: 10.1016/j.tranon.2025.102375

Authors: Antonios N. Gargalionis, Kostas A. Papavassiliou, Efthimia K. Basdra, Athanasios G. Papavassiliou

Institutions: National and Kapodistrian University of Athens, University General Hospital Attikon

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390