Work

A map of mitochondrial biology reveals the energy landscape of the human brain

Year: 2025

Type: article

Abstract: Mapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. Correlations between mitochondrial and brain-imaging metrics could enable future non-invasive explorations of mitochondrial bioenergetics in the brain in health and disease. A computational model can predict bioenergetics across the brain using standard neuroimaging data.

Source: Nature

DOI: 10.1038/d41586-025-00872-z

Authors: Sotiropoulos, Stamatios, Thiebaut de Schotten, Michel, Haber, Suzanne, Forkel, Stephanie

Institution: Institut des Maladies Neurodégénératives

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690