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CT imaging of and therapy for inflammatory bowel disease via low molecular weight dextran coated ceria nanoparticles

Year: 2025
Type: article
Abstract: CT imaging of mice subjected to dextran sodium sulfate (DSS) colitis showed that Dex-CeNP provided better contrast in the GIT of mice with colitis compared to iopamidol (ISO), with pronounced attenuation in the large intestine and disease- specific retention at 24 h. Additionally, Dex-CeNP significantly decreased Disease Activity Index (DAI) scores, and diminished gastrointestinal bleeding when compared with a currently approved drug, indicating that it is an effective treatment for colitis. Studies also revealed that the Dex-CeNPs were safe and well-excreted following administration. In summary, Dex-CeNP has significant promise as a dual-purpose agent for CT imaging and treatment of IBD.
Source: Nanoscale
DOI: 10.1039/d4nr04994b
Authors: Derick N. Rosario-Berríos, Amanda Y. Pang, Katherine J. Mossburg, Johoon Kim, Víctor R. Vázquez Marrero, Seokyoung Yoon, Mahima Gupta, Olivia C. Lenz, Leening P. Liu, Andrea C. Kian, Kálery La Luz Rivera, Sunny Shin, Peter B. Noël, Elizabeth M. Lennon, David P. Cormode
Language: English
Subfield: Genetics
Open Access status: hybrid
Awards: G1279845694, G2136266400, G2489094111, G4860184535, G6710817723, G9000102973, G9000283777, Cerium oxide nanoparticles for CT imaging and catalytic therapeutic intervention in inflammatory bowel disease
OpenAlex ID: W4408854448
FWCI: 6.05
Cites: 61
Cited by: 11
Related to: 10