Dynamics of Jugular Oxygen Saturation Level Using Target Temperature Control in Patients With Severe Traumatic Brain Injury
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Cerebral oxygenation level is an important prognostic factor in the treatment of patients with severe traumatic brain injury (TBI).Hypoxia, which significantly worsens clinical outcomes, can result from insufficient oxygen delivery to the brain or disrupted metabolism.The aim of this study was to investigate the effect of controlled normothermia on the oxygen saturation level in the jugular vein (SjvO2) in patients with severe TBI and hyperthermia.A total of 60 patients participated in the study, divided into a control group (n=30), which received standard antipyretic therapy, and an experimental group (n=30), where target temperature management was applied within the range of 36.5-37.5°Cusing the Blanketrol-II cooling system.Esophageal thermometry and invasive monitoring of SjvO2 levels were used.Statistical analysis was performed using standard methods via Jupyter Notebook (https:// jupyter.org).The study established that in the group with controlled normothermia, the SjvO2 level was significantly higher compared to the control group between days 3-7, reaching peak values on days 6-7.Correlation analysis revealed a strong inverse relationship between body temperature and SjvO2 levels, indicating worsening brain oxygenation with increasing hyperthermia.Thus, the obtained results confirm the effectiveness of controlled normothermia in improving cerebral oxygenation and suggest its use for optimizing intensive care in patients with severe TBI.
Authors: D. V. Oleniuk, A. V. Tsarov
Institution: Dnipro State Medical University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408854629