Work

Citrobacter rodentium

Year: 2025

Type: article

Abstract: Citrobacter rodentium is a Gram-negative bacterium that causes transmissible colonic crypt hyperplasia in mice. It is an extracellular pathogen that infects intestinal epithelial cells (IECs), primarily in the colon, while forming attaching and effacing (A/E) lesions. These lesions facilitate intimate bacterial attachment to the cell’s apical surface and effacement of the brush border microvilli, while also triggering cytoskeletal remodelling, leading to the formation of actin-rich pedestal-like structures upon which the bacterium ‘sits’.

Source: Trends in Microbiology

DOI: 10.1016/j.tim.2025.02.018

Authors: Sarah Jordan, Gad Frankel, Vishwas Mishra

Institution: Imperial College London

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030