Effective Spesolimab Treatment for Generalized Pustular Psoriasis Masquerading as Acute Generalized Exanthematous Pustulosis: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Generalized pustular psoriasis (GPP) is a rare and severe variant of psoriasis, often posing diagnostic challenges due to its clinical overlap with acute generalized exanthematous pustulosis (AGEP), a severe drug-induced hypersensitivity reaction. Spesolimab, a monoclonal antibody targeting the interleukin 36 (IL-36) receptor, provides rapid symptom relief for GPP flares, but real-world data remain limited. We report a case of GPP complicated by overlapping features with AGEP, highlighting the importance of precise diagnosis and the efficacy of spesolimab.
Source: Cureus
DOI: 10.7759/cureus.81254
Authors: Kazuyoshi Iijima, Yuko Akiyama, Itsumi Mizukawa, Megumi Hirabayashi, Yoshihiro Kuwano
Institution: Teikyo University Hospital, Mizonokuchi
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4408857758