Lifespan of male and female APP/PS1 and APP NL-F/NL-F mouse models of Alzheimer's disease
Year: 2025
Type: article
Abstract: Alzheimer’s disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP NL-F/NL-F ) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
Source: Journal of Alzheimer s Disease
Authors: Hannah Roberts, Yimin Fang, Kathleen Quinn, Tiarra Hill, Mackenzie R. Peck, Andrzej Bartke, Kevin N. Hascup, Erin R. Hascup
Institution: SIU Medicine
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408865400