Work

The association between glycated hemoglobin, physical activity and infertility: a multiple logistic regression and mediation analysis based on the NHANES database

Year: 2025

Type: article

Abstract: Objective To determine the relationship between physical activity (PA) patterns and infertility among women in the United States and to ascertain whether glycated hemoglobin (HbA1c) influences this association. Design A cross-sectional study of PA patterns and infertility was conducted. The PA classification was based on two categories: recreational PA and work-related PA. The subgroups were classified as inactive, less active, or active. We conducted data analysis via both multiple logistic regression analysis and mediation analysis. Setting National Health and Nutrition Examination Survey (NHANES, 2013–2018). Participants Women aged 18–49 years (n, 3,948). Results There was no statistically significant link demonstrated between infertility and work-related PA patterns. The recreational PA group may decrease the prevalence of infertility, with its occurrence being merely 0.79 times that of inactive group. (95% CI: 0.62, 1.0; p = 0.045). The consistency of this discrepancy was not preserved in Model III after the mixed effect was incorporated into the recreational PA group. The stratified research findings revealed that the association between recreational PA patterns and infertility was influenced by variables such as age, BMI, and history of diabetes. Furthermore, the mediation analysis revealed that recreational PA did not have a statistically significant direct effect on infertility (p = 0.098). HbA1c serves as a mediator in this interaction (95% CI: -0.06, -0.02). Conclusion Recreational PA patterns were associated with infertility among women aged 18–49 years in the United States, which was likely due to the effects of HbA1c.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2025.1495470

Authors: Panpan Chen, Leilei Zhu, Yanli Mou, Shuyun Zhao, Guanyou Huang

Institutions: Guiyang Medical University, Affiliated Hospital of Guizhou Medical University

Language: English

Topic: Reproductive Health and Technologies

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801