Indole alkaloids from Uncaria rhynchophylla and their inhibitory activities against α-glucosidase
Year: 2025
Type: article
Abstract: Sixteen indole alkaloids were isolated from the hook-bearing stems of Uncaria rhynchophylla (Rubiaceae family), including seven undescribed ones, uncarialines F-L ( 1 – 5 , 7 , and 8 ), and a naturally occurring alkaloid, 3-epicorynanthine ( 6 ). Among them, alkaloids 1 and 2 were identified as rare quaternary ammonium alkaloids, and alkaloid 7 exhibited an unprecedented indole alkaloid framework. Their structures were characterized by a comprehensive analysis of NMR, MS, ECD and single-crystal X-ray diffraction. Notably, alkaloid 5 demonstrate potent inhibitory activity against α -glucosidase, with an IC 50 value of 18.45 ± 0.77 μM. Furthermore, the inhibitory kinetics of α -glucosidase revealed that alkaloid 5 belong to the mix inhibition type. Molecular docking analysis showed that alkaloid 5 possessed superior binding affinity with α -glucosidase (−10.7 kcal/mol).
Source: Phytochemistry
Authors: Kepu Huang, Xuelin Chen, Sheng Li, Xinjian Zhang, Yumei Zhang, Yu Zhang
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,350
Funders: Chinese Academy of Sciences, Yunnan Provincial Science and Technology Department, Applied Basic Research Foundation of Yunnan Province, Applied Basic Research Key Project of Yunnan, National Key Research and Development Program of China, Major Science and Technology Project of Hainan Province
OpenAlex ID: W4408869390