Work

Vesicle inhibition reduces Candida biofilm resistance

Year: 2025

Type: article

Abstract: ABSTRACT Candida biofilm matrix components are delivered to the extracellular space by vesicles where they deposit and confer biofilm-associated drug resistance. Here, we present evidence that drugs designed to inhibit mammalian exosome production exhibit similar effects on C. albicans extracellular vesicles , ultimately eliminating biofilm matrix assembly. We find that vesicle reduction renders biofilm communities susceptible to the antifungal fluconazole. Our findings argue that vesicle trafficking pathways represent a promising target to optimize for recalcitrant fungal biofilms.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00045-25

Authors: Min-Ju Kim, Robert Zarnowski, Ryley Jones, Jeniel E. Nett, David Andes

Institutions: University of Wisconsin–Madison, William S. Middleton Memorial Veterans Hospital

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Institute of Allergy and Infectious Diseases