Work

Endotoxin-induced acute lung injury in old C57BL/6J mice is a translationally relevant geroscience model

Year: 2025

Type: article

Abstract: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically important inflammatory lung conditions that contribute to substantial morbidity and mortality in humans, notably in the elderly population. Direct lung infection is a common cause of ALI and can be modeled by experimental administration of lipopolysaccharide (LPS) bacterial endotoxin. Acute pulmonary pathology observations are presented using an intratracheal LPS-induced ALI experimental model in aged C57BL/6J mice. Collectively the histopathologic findings in LPS treated mice demonstrate several key characteristic features of ALI, supporting the translational relevance of this model for investigating the pathogenesis of lung injury in older adults.

Source: Aging Pathobiology and Therapeutics

DOI: 10.31491/apt.2025.03.170

Authors: Qianpei He, Ruby S. Mangalindan, Jenna Klug, Warren Ladiges

Institution: University of Washington

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute on Aging