Work

New Curvularin and Norlignanolide Derivatives From Cocultures of Marine Mangrove Endophytic Fungus Penicillium brocae MA‐231 and Phytopathogen Curvularia spicifera QA‐26

Year: 2025

Type: article

Abstract: A new curvularin derivative, curvulone C (1) and a pair of new norlignanolide diastereomers, aspergilfuranone E (2) and 8-epi-aspergilfuranone E (3), together with six known secondary metabolites (4-9) were isolated and identified from the coculture of the marine mangrove endophytic fungus Penicillium brocae MA-231 and phytopathogen Curvularia spicifera QA-26. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assigned on the basis of time-dependent density functional theory-electronic circular dichroism calculations. Compounds 1 and 4 showed inhibitory activities against several human and aquatic pathogens.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202500761

Authors: Ao‐Yuan Zhang, Xiao‐Shan Shi, Bin‐Gui Wang, Ling‐Hong Meng

Institutions: Chinese Academy of Sciences, Institute of Oceanology, Qingdao National Laboratory for Marine Science and Technology, University of Chinese Academy of Sciences

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Awards: G3368581203, G8144609821