Work

Nonwoven fabric coated with cerium oxide nanoparticles for viral inactivation and transmission Inhibition

Year: 2025

Type: article

Abstract: Studies on virus inactivation by metal nanoparticles indicate that antiviral activity is influenced by the stabilizer on the particle surface. Additionally, cerium oxide nanoparticles stabilized with boric acid (BA-CeO2) exhibit potent antiviral activity. However, previous studies utilized BA-CeO2 dispersed in liquid form and did not fully account for the practical application of antiviral materials in real-world environments. We investigated the antiviral activity of nonwoven fabric coated with BA-CeO2 (NC-NWF). When a medium containing viruses was placed on NC-NWF, the titers of mouse hepatitis virus (MHV), influenza A virus, and feline calicivirus were reduced by > 99% within 2 h. Furthermore, the transmission of MHV was assessed in cages lined with NC-NWF. The cages were divided into two compartments using a mesh and NC-NWF, housing infected and uninfected mice on either side. The results indicated a significantly lower antibody titer against MHV in naïve mice with the NC-NWF partition than in the control partition. Additionally, placing infected mice in NC-NWF cages for 2 h, followed by naïve mice for 24 h, resulted in lower antibody titers against MHV than those in the control fabric. These findings suggest that NC-NWF exhibits antiviral activity and retains efficacy in living environments, such as rearing cages.

Source: Scientific Reports

DOI: 10.1038/s41598-025-94199-4