Work

Placental lesions induced by Omicron SARS-CoV-2 in a pregnant woman treated with anti-CD20

Year: 2025

Type: article

Abstract: Since the emergence of SARS-CoV-2 in 2020, specific placental lesions characterized by a triad of trophoblastic necrosis, chronic histiocytic intervillitis, and massive perivillous fibrin deposits have been documented during pregnancy. After the arrival of the Omicron variant in late 2021, no placental lesions were observed at our institution until a recent case in September 2024 involving an immunosuppressed patient treated with anti-CD20. In this case, pathological analysis revealed the classic lesion triad, with strong immunohistochemical positivity for SARS-CoV-2. This suggests that placental tropism persists in certain variants several years after the emergence of SARS-CoV-2, necessitating vigilance in monitoring potential complications, especially in immunocompromised patients, regardless of variant classification. • A specific triad of placental lesions has been linked to SARS-CoV-2 during pregnancy since 2020. • Following the Omicron variant's emergence in late 2021, placental lesions had not been observed until a notable case in September 2024. • The 2024 case was in an immunosuppressed patient showing classic lesions and strong SARS-CoV-2 positivity. • The case shows placental tropism remains, though lower, in new SARS-CoV-2 variants years later. • Findings highlight the need for vigilant monitoring of placental issues in immunocompromised patients, regardless of variant class.

Source: Placenta

DOI: 10.1016/j.placenta.2025.03.015