Work

Breaking New Ground With Endoxifen: Augmentation Strategies in OCD Management—A Case Series

Year: 2025

Type: article

Abstract: Obsessive-compulsive (OC) disorder (OCD) is a common and potentially disabling illness with a waxing and waning course. OCD significantly disrupts the quality of life. Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for OCD and benefit up to half of the patients. Augmentation with low-dose antipsychotics is an evidence-based second-line strategy. Psychotherapy, including cognitive behavior therapy (CBT), is used both as first and second-line treatment. A significant portion of patients, however, do not respond to conventional treatments. We present a case series on the use of Endoxifen as an augmenting agent in patients with OCD and multiple psychiatric comorbidities who did not respond well to conventional pharmacotherapy.

Source: Case Reports in Psychiatry

DOI: 10.1155/crps/2908673

Authors: Rishabh Singh, Markanday Sharma, Samiksha Sahu, Arka Adhvaryu

Institutions: Eastern Command Hospital, Gandhi Medical College, R. G. Kar Medical College and Hospital

Language: English

Topic: Obsessive-Compulsive Spectrum Disorders

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790