Analysis of high-risk stocker cattle transcriptome associates clinical BRD with consistent inflammation-related pathways
Year: 2025
Type: conference-paper
Abstract: Although bovine respiratory disease (BRD) is frequent and costly in beef cattle operations, diagnosis of the disease complex is inaccurate. Metaphylactic use of antimicrobials effectively reduces the risk of BRD, but antimicrobial administration may induce resistance. Therefore, this project was designed to identify differences in levels of transcribed gene expression driven by clinical BRD, both with and without administration of metaphylaxis at-arrival in high-risk stocker cattle. Using RNA sequencing, we aimed to identify predictive gene expression pathways at-arrival in cattle that developed BRD or not, characterize host genomic patterns in response to clinical BRD, and describe differences in gene expression of clinically diseased cattle based on treatment success and time of treatment within the study.
Authors: H.M. Prosser, B.I. Ramirez, R.J. Valeris-Chacin, W.B. Crosby, A.R. Woolums, B.B. Karisch, E.C. Baker, M.A. Scott
Institutions: West Texas A&M University, Mississippi State University
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4408882921