Feasibility analysis and efficacy evaluation of CT-guided microwave ablation combined with radioactive 125-I particles in the treatment of lung nodules
Year: 2025
Type: article
Abstract: INTRODUCTION: I seed implantation. Our study retrospectively analyzed 58 lung nodule patients treated with MWA in combina- tion with simultaneous or delayed radioactive particle implantation to evaluate the impact of implant radiation therapy on patient outcomes and complicaton rates. AIM: I seed implantation for treating ipsilateral single pulmonary nodules. MATERIALS AND METHODS: I seed implantation was performed 1 week after MWA or after resolution of complications. Data on clinical outcomes, complications, and chest CT findings at 1, 3, and 6 months after the procedure were collected. RESULTS: All procedures were completed with a 100% technical success rate. Complication rates (hemopty- sis, pneumothorax, pleural effusion) were similar in both groups (P = 0.76, P = 0.8, P = 0.7, respectively), whereas duration of hospitalization was longer in the control group (P = 0.03). At 3 months, the total effective rate was 70% in the control group and 75% in the experimental group (P = 0.67), with 100% local control in both groups. At 6 months, the total effective rate was 80% and 82.1%, respectively (P = 0.84), with continued 100% local control. CONCLUSIONS: Combining CT-guided biopsy with immediate MWA and particle implantation for ipsilateral single pulmonary nodules does not increase the incidence of complications. Specimens are suitable for clinical and pathological testing, and lesion control rates meet clinical standards. This combined approach is feasible and safe.
Authors: Shan Yu-Qing, Lin Fan-Xia, Wang Li, Wang Hai-Yu
Institution: People’s Hospital of Rizhao
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,480
OpenAlex ID: W4408887550