Work

Suppression of LIF in tumor-associated macrophages contributing to the PD-1/PD-L1 blockade in hepatocellular carcinoma

Year: 2025

Type: article

Abstract: • Effective therapy is achieved as Kang Ai (KA) injection significantly increases the proportion of pro-inflammatory macrophages and CD8 + T cells. • PD-1/PD-L1 blockade demonstrates increased responsiveness and decreased immunotoxicity when used in combination with KA injection. • Activation of the LIF/HMGA2/CYR61 pathway promotes macrophages M2 polarization, while KA injection inactivates this pathway.

Source: Journal of Pharmaceutical Analysis

DOI: 10.1016/j.jpha.2025.101286

Authors: Shuangshuang Yin, Yanming Luo, Miaomiao Jiang, Lifeng Han, Sibao Chen, Leilei Fu, Yuling Qiu, Haiyang Yu

Institutions: Tianjin University of Traditional Chinese Medicine, Hong Kong Polytechnic University, Southwest Jiaotong University, Tianjin Medical University

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Tianjin City

Awards: G1542646834, G1803886723, G4637427272, G4747448192, G5889280011, G7253530582

OpenAlex ID: W4408901816

FWCI: 0.305

Cites: 6

Cited by: 1

Related to: 10