Value analysis of serum β -HCG, AMH, and P/E2 for predicting freeze-thaw embryo transfer outcomes in patients with thin endometrium
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: To analyze the value of serum human chorionic gonadotropin (β-HCG), anti-Mullerian hormone (AMH), progesterone (P)/ estradiol (E2) in predicting the pregnancy outcome of frozen-thawed embryo transfer (FET) cycle in patients with low profile endometrium. Methods: In this retrospective study, 120 patients with low-profile endometrium who received FET therapy in the reproductive center of Maternity & Child Care Center of Qinhuangdao from October 2019 to February 2023 were included. Serum β-HCG, AMH, and P/E2 levels were measured on the day of FET transplantation. After 30 days they were divided into pregnancy group and non-pregnancy group according to whether they were pregnant. The risk factors affecting the cycle pregnancy rate of FET were analyzed. The values of β-HCG, AMH, P/E2 and the combination of the three in predicting the periodic pregnancy rate of FET in patients were analyzed. Results: Logistic regression analysis showed that age (≥35 years), type of infertility (primary infertility), transplanted fetus, moderate and severe intrauterine adhesions and P, P/E2 levels were risk factors for the periodic pregnancy rate of FET (OR > 1, P<0.05). The ROC curve showed that the AUC of serum β-HCG, AMH, P/E2 and their combination to predict the pregnancy rate of FET cycle in patients with thin endometrium was 0.83(95%CI:0.741-0.910), 0.86(95%CI:0.788-0.922), 0.75(95%CI:0.662-0.838), and 0.88(95%CI:0.807-0.947). Conclusion: Serum β-HCG, AMH, and P/E2 are closely related to the cycle pregnancy rate of FET in patients with thin endometrium. Therefore, dynamic monitoring of the changes of three indicators should be conducted clinically. doi: https://doi.org/10.12669/pjms.41.4.9980 How to cite this: Yan Y, Zhang J, Li W, Yin X. Value analysis of serum β -HCG, AMH, and P/E2 for predicting freeze-thaw embryo transfer outcomes in patients with thin endometrium. Pak J Med Sci. 2025;41(4):973-978. doi: https://doi.org/10.12669/pjms.41.4.9980 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Authors: Yani Yan, Jian Zhang, Weiwei Li, Xiurong Yin
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $400
OpenAlex ID: W4408902191