Work

HBV infection and pregnancy: Increased risks of gestational diabetes and preterm birth

Year: 2025

Type: article

Abstract: Objective: To investigate the effects of Hepatitis B virus (HBV) infection status on the outcomes of pregnancy. Methods: A retrospective study was conducted at Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde) from 1st January 2020 to 31st December2022.The study included 13,980 pregnant women, with 1,059 in the HBsAg-positive group (study group) and 12,921 in the HBsAg-negative group (control group). Pregnancy outcomes were compared between the control and study groups. Results: Pregnant women who tested positive for HBsAg had higher rates of gestational diabetes mellitus (P=0.019; OR, 1.20; 95% CI, 1.03-1.40), intrahepatic cholestasis of pregnancy (P=0.019; OR, 1.85; 95% CI, 1.11-3.09) and preterm birth before 34 weeks (P=0.013; OR, 1.96; 95% CI, 1.15-3.34). The relationship between HBV infection status with gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and preterm birth before 34 weeks was significant. Conclusions: Pregnant women who tested positive for HBsAg faced a higher likelihood of developing gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and giving birth prematurely before 34 weeks. Further clarification is required regarding the influence of HBV infection on the outcomes of pregnancy. doi: https://doi.org/10.12669/pjms.41.4.9578 How to cite this: Cai X, Huang S, Ma Z. HBV infection and pregnancy: Increased risks of gestational diabetes and preterm birth. Pak J Med Sci. 2025;41(4):952-957. doi: https://doi.org/10.12669/pjms.41.4.9578 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Source: Pakistan Journal of Medical Sciences

DOI: 10.12669/pjms.41.4.9578

Authors: Xiumei Cai, Suiping Huang, Zuliang Ma

Institutions: Guangzhou University of Chinese Medicine, The First People's Hospital of Shunde, Southern Medical University

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $400