lncRNA EGOT Is the Marker of HPV Infection and a Prognostic Factor for HNSCC Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: High-risk human papillomavirus (HPV) contributes to oropharyngeal cancers through mechanisms involving the deregulation of host cell functions by oncoproteins E6 and E7. Changes in the epigenome, particularly involving long non-coding RNAs (lncRNAs), are crucial for understanding HPV-related carcinogenesis. Methods: This study aimed to analyze the expression levels of lncRNAs in HPV-related head and neck squamous cell carcinoma (HNSCC) to determine their biological and clinical significance, addressing the current gap in clinically validated biomarkers for early screening and therapeutic interventions. Results: The study highlights the significant overexpression of the EGOT gene in HPV-positive HNSCC samples, suggesting its potential as a marker to distinguish between HPV-negative and HPV-positive cases. Furthermore, high EGOT expression correlates with better overall survival (OS) and indicates possible resistance to therapy, making it a valuable prognostic factor. Conclusions: These findings underscore the potential of incorporating EGOT expression analysis in clinical practice for improved patient stratification and treatment outcomes in HNSCC.
Source: Biomedicines
Authors: Tomasz Kolenda, Piotr Białas, Kacper Guglas, Maciej Stasiak, Joanna Kozłowska-Masłoń, Karina Tylkowska, Anna Zapłata, Paulina Poter, Marlena Janiczek-Polewska, Patrycja Mantaj, Paulina Gieremek, Urszula Kazimierczak, Anna Przybyła, Katarzyna Regulska, Beata Stanisz, Ewa Leporowska, Andrzej Mackiewicz, Jacek Mackiewicz, Joanna Kazmierska, Zefiryn Cybulski, Anna Teresiak
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
Award: G6126038804
OpenAlex ID: W4408902401