Work

MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation

Year: 2025

Type: article

Source: ACS Chemical Biology

DOI: 10.1021/acschembio.4c00864

Authors: Shelton R. Boyd, Srinivas Chamakuri, Alexander J. Trostle, Hu Chen, Zhandong Liu, Antrix Jian, Jian Wang, Anna Malovannaya, Damian W. Young

Institutions: Baylor College of Medicine, Neurological Research Institute, Texas Children's Hospital

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Bill and Melinda Gates Foundation, Cancer Prevention and Research Institute of Texas, Adrienne Helis Malvin Medical Research Foundation, Baylor College of Medicine

Awards: G1214464124, G2050011613, Recruitment of First-Time, Tenure-Track Faculty Members, G5109157691, Baylor College of Medicine - to apply additional target validation and prioritization filters to a portfolio of potential male contraceptive drug targets that could accelerate ..., G905522293

OpenAlex ID: W4408903524

FWCI: 5.222

Cites: 49

Cited by: 20

Related to: 10