Work

Importance of prenatal diagnosis and multidisciplinary care in orofacial cleft: Report of three cases. Embryology understanding and risk factors

Year: 2025

Type: article

Abstract: Orofacial clefts are common, severe craniofacial malformations. Fetal anatomy assessment is able to detect fetal face defects as early as the first trimester ultrasound scan. The aim of our study is to highlight the importance of prenatal diagnosis. We present three cases of orofacial clefts diagnosed at different times after conception by ultrasound examination. 2D and 3D US assessments were performed, and in addition to the cleft palate, a cleft lip was present, which was not visible earlier due to the limitation of the earliest gestational age. Counseling with oral and maxillofacial surgery specialists was obtained, and the delivery took place in a tertiary hospital. Assessment of risk factors that increase the likelihood of orofacial cleft as well as an accurate prenatal diagnosis are essential for timely management by a multidisciplinary care team.

Source: Pharmacia

DOI: 10.3897/pharmacia.72.e148523

Authors: Elitsa Deliverska, Maria Aleksandrova, Petya Chaveeva

Institutions: Medical University of Sofia, Dr. Shterev Hospital, Medical University Pleven

Language: English

Topic: Cleft Lip and Palate Research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107