Modern approaches to the treatment of obstetric surgical wound infection in postpartum women
Year: 2024
Type: article
Study design: Clinical Trial
Abstract: Aim - to determine the effectiveness of treating obstetric surgical wound infection in parturient women with drugs with both sorption-detoxification and immunomodulatory properties Materials and methods. To achieve the goal of the study, 115 women in labor with purulent wounds of the anterior abdominal wall (after cesarean section) and perineum (episiotomy, perineotomy) were examined and treated, who, depending on the treatment method, were divided into groups. The Group I - 42 women in labor with purulent wounds, who were treated with the organosilicon sorbent Gentaxan (application sorption); the Group II - 45 women in labor with purulent wounds, who were treated with the organosilicon sorbent Gentaxan (application sorption) and the immunomodulator Laferon (intramuscularly); the Group III (control) - 28 women in labor with purulent wounds, who were treated with traditional methods. To determine the course and effectiveness of treatment of purulent wounds, the structure of biological media (blood, wound exudate) and substrate - biopsy from the wound in the solid phase, which were taken before, during (3, 5-6, 8-9 days) and after treatment. Results. The analysis of crystallograms of blood smears and wound biopsy showed the advantage of complex treatment with gentaxane and laferon over monotherapy with gentaxane and traditional treatment methods, due to an additional reduction in the healing time of the wound (by 1.5 - 2 days; by 5-6 days), which allowed us to recommend it for use in the treatment of purulent wounds in obstetric departments. Conclusions. Thus, complex therapy of purulent wounds with drugs with sorption-detoxification and immunomodulatory properties increases the effectiveness of treatment, accelerating the course of reparative processes in the wound, which prevents contamination of wounds of women in labor with hospital infection and further spread of the inflammatory process. The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution specified in the work. Informed consent of the parents of women in labor was obtained for the study. The authors declare no conflict of interest.
Institution: Bogomolets National Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408904885