Work

Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression

Year: 2025

Type: article

Abstract: simultaneously promoting M2 macrophage polarization and anti-angiogenesis effect by decreasing the endothelial cell migration and tube formation. The combined Ber and Sin further amplified these effects. The therapeutic microneedle patch (B/S-TM@MN) significantly decreased the expression of CD68-positive macrophages and CD31-stained blood vessel, attaining improved anti-arthritis efficacy compared with monotherapies in the collagen-induced arthritis (CIA) mouse model. Our work represents a promising strategy for targeting multiple pathological factors for enhanced anti-RA therapy.

Source: Biomaterials Science

DOI: 10.1039/d5bm00036j

Authors: Peng Hua, Suleixin Yang, Lin Yu, Yongzhuo Huang, Meiwan Chen

Institutions: University of Macau, Fudan University, Chinese Academy of Sciences, Shanghai Institute of Materia Medica

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: United Mitochondrial Disease Foundation, Universidade de Macau, Fundo para o Desenvolvimento das Ciências e da Tecnologia