Year: 2025
Type: conference-paper
Abstract: Dairy calves have the necessary immune cell machinery to mount an effective immune response. However, their lymphocytes often fail to fully respond to parenteral vaccination until 6 months of age, limiting vaccine effectiveness during the first months of life. Lymphocytes’ mitochondrial functionality drives effector functions critical for vaccine responsiveness. However, the extent to which lymphocyte mitochondrial function changes with age and could explain this poor vaccination response remains unknown. Thus, we aimed to determine how the mitochondrial function of dairy calf lymphocytes changes with age from birth to immunologic maturity. Given lymphocyte dependency on mitochondrial efficiency, we hypothesized that the mitochondrial efficiency of dairy calf lymphocytes increases with age.
Authors: K. Kesler, A. Abuelo
Institution: Michigan State University
Language: English
Topic: Animal health and immunology
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408911013