Work

Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis

Year: 2025

Type: preprint

Abstract: In addition to the issues pointed out in Tabin et al 1 , the MZR data from Zhang et. al 2022 2 are suggestive of high levels of contamination from a source similar to modern Han Chinese, the majority population in the country where MZR was sequenced. In fact, MZR can be modeled entirely as Han-related ancestry and noise. These results raise further concerns about the veracity of the MZR data and thus the paper’s historical conclusions.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2025.03.24.645126

Authors: Daniel Tabin, Nick Patterson, Matthew Mah, David Reich

Institutions: Harvard University, Broad Institute, Howard Hughes Medical Institute

Language: English

Topic: Forensic and Genetic Research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Human Genome Research Institute

Award: Advanced tools for using ancient DNA to study biology and history

OpenAlex ID: W4408912940

Cites: 12

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Related to: 10