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NSAID Induced Spontaneous Rectal Perforation

Year: 2025

Type: article

Abstract: NSAID related spontaneous rectal perforation is a rare and severe condition with potentially life-threatening outcomes. We report a case of a 75-year-old woman with a mid-rectal perforation related to prolonged NSAID use. She presented with sudden rectal and lower abdominal pain. Imaging revealed a localised gas collection in the pre-sacral space without widespread peritonitis. Management included laparoscopic loop sigmoid colostomy and IV antibiotics. The patient recovered well and showed complete resolution at follow-up. This case highlights the importance of judicious use of NSAIDS in high-risk patients and underscores the need for individualised management strategies.

Source: Frontiers in Medical Case Reports

DOI: 10.47746/fmcr.2025.6103

Authors: Maheen Rana, Patricia Pantilie, Ben O’Sullivan, Robert Hannon

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4408913156

FWCI: 0.483

Cites:

Cited by: 1

Related to: 10