Association between composite dietary antioxidant index and increased urinary albumin excretion: a population-based study
Year: 2025
Type: article
Abstract: Introduction The Albumin-Creatinine Ratio (ACR) is a key biomarker for early kidney disease detection and is predictive of chronic kidney disease (CKD) progression and associated cardiovascular risks. Antioxidant diets, indicated by the Composite Dietary Antioxidant Index (CDAI), may reduce oxidative stress and alter albumin urinary excretion rates. This study explores the relationship between CDAI and albuminuria. Materials and methods Data on intake of vitamins A, C, E, zinc, selenium, and beta-carotene from the NHANES database (2007–2018) were used to compute CDAI scores. To measure urinary albumin, the ACR levels were assessed. The association between CDAI and ACR was analyzed through multivariate logistic regression, subgroup analysis, and interaction tests, incorporating a generalized additive model (GAM) to evaluate potential non-linear relationships. Results A total of 28,601 participants were included with an average CDAI of 0.302 ± 3.895. Those in higher CDAI quartiles showed a reduced likelihood of elevated ACR. The prevalence of increased ACR decreased across the CDAI quartiles from 13.89% in Q1 to 10.11% in Q4. Higher CDAI scores were inversely related to ACR (OR: 0.99, 95% CI: 0.97–1.00), with a significant interaction effect by BMI (p = 0.0048). In males, a distinct L-shaped relationship was noted, with a negative correlation between CDAI and ACR to the left of the inflection point at 0.53 (OR: 0.95, 95% CI: 0.91–0.98). Conclusion Increasing CDAI is associated with lower ACR and reduced risk of albuminuria, suggesting that dietary antioxidants may benefit renal and cardiovascular health.
Source: Frontiers in Nutrition
Authors: Shaopeng Li, Suqiong Yang, Yong Wang, Zongqi Lin, Fuyuan Chen, Qinghe Gao, Jiantong Cai
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408915156