Work

Role of Polyadenylation in mRNA Genome Integration via LINE-1 Retrotransposons: An Opinion on mRNA Vaccine Safety

Year: 2025

Type: article

Abstract: The polyadenylated (polyA) tail of mRNA plays a crucial role in regulating mRNA stability and translation, and it may also contribute to genome integration through interactions with long interspersed nuclear element-1 (LINE-1, L1) retrotransposons. This interaction is particularly relevant for mRNA vaccines. Understanding how the polyA tail interacts with L1 proteins, especially open reading frame 2 protein (ORF2p), is critical for assessing these risks and developing strategies to enhance the safety of mRNA vaccines. We suggest conducting in vitro experiments to explore polyA tail modifications and their effects on L1 binding.

Source: Frontiers in Bioscience-Scholar

DOI: 10.31083/fbs26335

Author: Isidoro Feliciello

Institutions: Federico II University Hospital, University of Naples Federico II

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500