Work

Symptomatic bone marrow metastasis in triple-negative breast cancer: a case report and literature review

Year: 2025

Type: article

Abstract: Bone metastasis is common in breast cancer, but symptomatic bone marrow involvement is exceedingly rare. This report presents a case of a young female patient with triple-negative breast cancer (TNBC) initially presenting with symptomatic bone marrow metastasis. Upon admission, blood tests revealed severe thrombocytopenia. Bone marrow biopsy confirmed tumor cell infiltration, and immunohistochemistry identified metastatic breast cancer cells. The patient received paclitaxel and eribulin chemotherapy combined with transfusion support, achieving significant symptom control. This rare case highlights the importance of early detection and aggressive management in TNBC with bone marrow metastasis.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1570355

Authors: Chenhui Zheng, Jingjing Dai, Yu Wang, Danni Zheng, Renzhi Lin, Zhibao Zheng

Institution: Taizhou Central Hospital

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801