Work

PHAGOVITA—Composition and Characterization of Novel Phage Pastilles

Year: 2025

Type: article

Abstract: Infections of the oral cavity and upper respiratory tract, commonly caused by pathogens such as Streptococcus , Staphylococcus , Enterococcus , and Escherichia coli , are often treated with over-the-counter antibacterial pastilles. However, the rise of antimicrobial resistance has diminished the efficacy of these treatments. In response, PHAGOVITA, a new phage-containing pastille, was developed. The formulation includes bacteriophages from the “Pyophage” and “Intestiphage” cocktails and eucalyptus oil as active pharmaceutical components and other stabilizing agents. The combination of bacteriophages and eucalyptus oil enhances its broad-spectrum therapeutic properties. PHAGOVITA demonstrated stable phage activity over 2 years and exhibited antimicrobial activity against 91% of 430 tested bacterial strains. These findings highlight PHAGOVITA’s potential as a safe and effective alternative therapy for treating oral and upper respiratory tract infections, particularly in the context of multidrug-resistant bacterial pathogens.

Source: PHAGE

DOI: 10.1089/phage.2024.0055

Authors: Sophio Rigvava, Ia Kusradze, Natia Karumidze, Irine Chkonia, Nino Tatrishvili, Aliko Bakuridze, Lasha Bakuridze, Dali Berashvili, Vakhtang Pavlenishvili, Marina Goderdzishvili

Institutions: Caucasus International University, George Eliava Institute of Bacteriophage, Microbiology and Virology, European University, Tbilisi State Medical University

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Ecology

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408918661

FWCI:

Cites: 14

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Related to: 10