Work

Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus Aspergillus sp. NF666

Year: 2025

Type: article

Abstract: Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (1) and D (2) were isolated from the marine-derived fungus Aspergillus sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (1 and 2) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (2) in this work.

Source: Molecules

DOI: 10.3390/molecules30071502

Authors: Fangwen Jiao, Tianyu Liu, Kaiwei Wang, Shuai Li, Ruihua Jiao, Wei Lin

Institutions: Nanjing University of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258