Role of basal-topographic pH-metry of stomach in management of patients with chronic recurrent pancreatitis in case of comorbidity
Year: 2025
Type: article
Study design: Observational Study
Abstract: The comorbidity of chronic recurrent pancreatitis (CRP) and chronic gastritis (CG) and/or chronic duodenitis (CD) associated with Helicobacter pylori remains poorly understood. The progression of such comorbidity affects the clinical symptoms, is accompanied by morphological changes of the mucous membrane, a violation of the acid‑producing function of the stomach. In the prism of studying the influence of gastroduodenal disorders on CRP, it is relevant to perform basal‑topographic express‑pH‑metry, which makes it possible to determine the state of acidity in the stomach, as well as the possibility of providing the patient with the fastest and most appropriate differentiated treatment (treatment selection and control). Objective — to determine the state of basal‑topographic acidity of the stomach in patients with isolated CRP, as well as in its comorbidity with CG and/or CD associated with H. pylori, in order to optimize the tactics of management of such patients in clinical practice. Materials and methods. The study included 147 patients registered as out‑patients and under the supervision of a family doctor in the Center for Primary Health Care. The main group consisted of 117 patients with CRP in combination with CG and/or CD associated with H. pylori and 30 patients with isolated CRP. All patients underwent basal‑topographic pH‑metry along the course of the stomach. The results were evaluated using the proposed functional intervals (FI) of pH (FI pH) from 0 to 5 (in the direction of increasing gastric acidity) and unimodal analysis of One‑way ANOVA followed by post‑hoc Tukey HSD test. Results. The following ranking of the distribution of measurement points in patients with CRP in the intervals of basal‑topographic express pH‑metry was revealed, starting with the highest (р <0.05): 3 – 2 >4 – 5 – 1, which indicates the predominance of normacidity with a tendency to moderate hypoacidity, and in patients with CRP and CG and/or CD associated with H. pylori — 4 >5 >3 >2 – 1, (р <0.05), which indicates moderate hyperacidity with a tendency to pronounced hyperacidity. Conclusions. Moderate hyperacidity with a tendency to pronounced hyperacidity has been proven in patients with comorbidity of CRP and CG and/or CD associated with H. pylori, according to the revealed rating of the distribution of measurement points in the intervals of basal‑topographic express pH‑metry, which requires mandatory correction.
Source: Modern Gastroenterology
Authors: L. S. Babinets, I. V. Makhnitska
Institution: I.Horbachevsky Ternopil National Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408921003