Work

A rare case of multiple myeloma with double translocations: t(11;14) and t(14;16)

Year: 2025

Type: article

Abstract: Multiple myeloma is a clonal plasma cell malignancy often characterized by complex cytogenetic abnormalities that influence prognosis and treatment strategies. This report describes a 63-year-old male with kappa light chain multiple myeloma and a rare finding of double translocation involving t(11;14) and t(14;16), detected by FISH analysis. This case emphasizes the clinical implications of such genetic abnormalities and their impact on disease progression and therapeutic decisions.

Source: Journal of Hematopathology

DOI: 10.1007/s12308-025-00626-w

Authors: Mina Meseha, Vishw Patel, Kirolos Sekla, Ping Yang, David Coffey

Institutions: University of Miami, Cleveland Clinic, Alexandria University

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890