Fragrances of Cage Bicyclic Benzene Bioisosteres
Year: 2025
Type: article
Abstract: Cubane, bicyclo[1.1.1]pentane (BCP) and bicyclo[2.2.2]octane derivatives of benzene-containing fragrances (e. g., benzyl esters) were prepared to evaluate whether odor characteristics would be retained to give same or similar scents. It was observed that each molecule maintained a distinctive aroma, sometimes quite similar to the benzene ring containing fragrance, and in other cases very different, with several perceived to produce high intensity odors. These results suggest that saturated cage bicyclic hydrocarbon bioisosteres have potential as new tools for the discovery of novel fragrances.
Source: Chemistry - A European Journal
Institutions: The University of Queensland, CSIRO Manufacturing
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
Funder: University of Queensland
OpenAlex ID: W4408922004